Sublingual misoprostol for induction of labour. html>ki

3. 1 Vaginal misoprostol has been shown to be more efficacious than oral misoprostol in equivalent doses. Sublingual misoprostol in the induction of labour at term [abstract]. 72%, P=0. Br J Obstet Gynaecol. Aim: This study aimed to evaluate the effect of pre-labour administration of sublingual misoprostol versus oxytocin in term PROM on maternal and fetal outcomes. , 2016). Oct 30, 2014 · To compare the efficacy and safety of 50 mcg of sublingual misoprostol with 25 mcg of vaginal misoprostol for induction of labour at term. 200 women with singleton term pregnancy, admitted for induction of labour, were randomized to receive either 25 mcg of vaginal misoprostol or 50 mcg induction of labor (including oxytocin) and observed that it was associated with fewer cesarean sections [9 ]. Sublingual route of administration was associated with higher incidence of Hyperstimulation. Medicine. If using oral misoprostol, the evidence suggests that the dose should be 20 to 25 mcg in solution. Setting: Tertiary level UK Hospital. 11 h, 95% CI – 2. Since then, several randomized trials have been published and an update is indicated to review current knowledge as, to date, there is no consensus on the optimal route of misoprostol intake for induction of labour. Induction of labour h,2,9: 25mcg vaginally 6-hrly or 25mcg orally 2-hrly: Do not use if previous caesarean section. Dosage of oral misoprostol in both works was 25 μg every 2 Dec 6, 2022 · Sublingual misoprostol was superior compared to vaginal misoprostol in reducing the interval from induction to delivery (MD – 1. 85 Primary outcomes Misoprostol, a synthetic prostaglandin E 1 analog, has been given both orally and vaginally for induction of labor at term. This is not a complete list of side effects and others may occur. One hundred women 2. The prostaglandin E1 Aug 1, 2006 · Abstract. A comparison of oral and vaginal misoprostol tablets in induction of labour at term. [Google Scholar] Shetty A, Danielian P, Templeton A. Methods: One Apr 1, 2012 · To describe the maternal and perinatal outcomes after the use of 12. PPH prophylaxis i,2,10/j,11 (secondary preventation) 600mcg orally single dose Objective: To evaluate the effectiveness and safety of different administration routes of misoprostol for induction of labor. 1. CAS Google Scholar Nassar AH, et al. Apr 6, 2022 · Introduction. Methods: A total of 100 p atients wer e alternately assigned to induction with either titrated (low-dose) misoprostol solution and buccal/sublingual misoprostol hadthe highest likelihood ofbeingcost-effective” (7). Compared with those receiving oral misoprostol, Foley catheter recipients had a slightly decreased chance of vaginal birth (risk ratio (RR), 0. dehydration --dizziness, confusion, feeling very thirsty, less urination. Conclusion: Sublingual misoprostol is as effective as vaginal misoprostol for induction of labor at term. FYI, the generic name of Cytotec is Misoprostol. Dosage of oral misoprostol in both works was 25 μg every 2 To evaluate the effectiveness and safety of different administration routes of misoprostol for induction of labor. Table 2 Meta-analysis of oral misoprostol compared with vaginal misoprostol for labor induction Odds ratio (OR) 95% CI 9 1. This study compared the efficaciousness of sublingual, vaginal, and buccal misoprostol for inducing labor in a full-term pregnancy. 86, 87 The Cochrane Pregnancy and Childbirth Group reviewed randomized trials comparing vaginal misoprostol with placebo, oxytocin, or prostaglandin E 2 for cervical ripening or induction of a viable fetus in the third trimester. . Sublingual misoprostol significantly reduces the induction-to-delivery interval and has fewer induction failures; thus, it could contribute towards reducing the morbidity Apr 10, 2020 · Background Labor induction is defined as any procedure that stimulates uterine contractions before labor begins spontaneously. The cesarean section rate was less in the oral misoprostol compared with the vaginal misoprostol groups (22. Time interval from induction to the beginning of active phase of labour was similar in both groups. 747 Aug 16, 2005 · Method: PubMed, Cochrane Library and EMBASE searches were carried out using the keywords oral, vaginal, sublingual, buccal, misoprostol, labor induction, identifying randomized case–controlled trials comparing different routes for giving misoprostol to induce labor, published in English between 1994 and 2004. Given that safety is the primary concern, the evidence supports the use of oral regimens over vaginal Dec 29, 2015 · Ultimately, this study demonstrated that sublingual misoprostol is a safe and cost-effective method of labour induction compared to intracervical dinoprostone gel (Veena et al. Karamali A. Recent advances in analytical technology now make it possible to detect low concentrations of plasma MPA, and to study the PKs of misoprostol at low doses used for labor induction at term. 1%; OR 0. Delivery within 24 h after induction with oral misoprostol solution was the primary outcome on which the sample size was based. Induction of labor (IOL) is recommended where there is a clear medical indication and the expected benefits outweigh its potential harms Citation 1. The frequency of misoprostol administration should not exceed 3 to 6 hours. 5. 95 (95% CI, 0. 99); I 2 , 2. 7). Oral misoprostol is both as or more effective and safe than other methods of induction of labour. Common misoprostol side effects may include: diarrhea and stomach pain. 02241 Feb 13, 2022 · The current and Pourali's studies utilized the same sublingual route of misoprostol to labor induction. 14 Other routes for the use of misoprostol in labor induction, including buccal and sublingual administration, have been less studied. Sublingual misoprostol is similarly effective as vaginal misoprostol at promoting vaginal delivery, but with a higher risk of tachysystole. Nevertheless, the sublingual route may reduce the number of vaginal examinations required 2. Objectives: To determine, using the best level of evidence available, the efficacy and safety of sublingual administration of misoprostol compared with vaginal misoprostol in the third trimester of pregnancy for the induction of labour, according to initial doses, in women May 19, 2022 · PKs of misoprostol administered for full-term labor induction have been challenging to study due to the low (25–50 μg) doses used for this indication. The dose was repeated every 4 hours to a maximum of 5 doses if indicated. Sample: Two hundred and fifty women at term with indications for labour induction. Sublingual administration offers an excellent choice to women, particularly to those who were wishing to avoid vaginal administration. 5, 95% CI 0. 2018; 38 : 167-171 Crossref The most common initial dose of misoprostol was 25 mcg in the vaginal (95. 3-0. 0%; moderate-certainty evidence). ‘Induction of Labour’ below. Background: This is one of a series of reviews of cervical ripening and labour induction using standardised methodology. Jul 10, 2018 · Safety and effectiveness of oral misoprostol versus oxytocin for labor induction in term pregnancy. 11 However, the misoprostol group had a higher incidence of hyperstimulation, meconium-stained amniotic fluid, and fetal distress. A trend towards a lower rate of composite adverse Oct 27, 2021 · Conclusion: In addition to the sublingual and intravaginal routes of administration, intracervical misoprostol at a single dose of 50μg appears to be an effective method for induction of labor in Feb 16, 2017 · Objective To compare the effectiveness and safety of sublingual versus vaginal misoprostol on improving the Bishop score after 6 h of administration. Methods Randomized clinical trial which includes pregnant women in gestational ages from 32/0 to 41/6, with indication of induction of labor with misoprostol. of sublingual misoprostol and intracervical dinoprostone gel for induction of labor in primigravida women. Our results showed that 50 µg of sublingual misoprostol resulted in a higher, although nonsignificant, rate of successful vaginal deliveries when compared with the same dose given vaginally (76 vs. Women in the group A were given 100 microg of For fetal death in the third trimester see 'Induction of Labour' below. Harandi and Peter reported the effect of oral misoprostol for induction of labor from Iran to Nigeria in 2013 and 2019, respectively. Methods: This double-blind clinical trial randomized 150 women to receive every 6 h 25 μg of sublingual misoprostol and vaginal placebo or 25 μg of vaginal misoprostol and sublingual placebo. Methods: Two hundred nulliparous women with single live fetus and with gestational age of more than 37 weeks admitted for induction of labor were recruited for the study. Misoprostol in solution is easy to prepare and administer, has an advantageous 2 hour half-life, and allows for titratable dosing while maintaining a maximum dose in the low dose range (≤ 50 μg) ( high ). PPH prophylaxis i,2,10/j,11 (secondary preventation) 600mcg orally single dose Oct 6, 2010 · Third trimester cervical ripening and labour induction with misoprostol have been reported using the oral, vaginal, rectal and buccal/sublingual routes. Low Weak 2. Low Weak 3. Clinical experience with misoprostol for labour induction has been reviewed by Wing ( Wing 1999b ). The aim of the study was to compare the efficacy and safety profile of sublingual misoprostol (PGE1) versus intracervical dinoprostone gel (PGE2) for induction of labor. We conducted a multicenter Results: Despite a similar proportion reporting the labour induction as more painful than expected in both groups, a significantly lower proportion mentioned that the pelvic examinations were very painful in the sublingual group (19. Only one woman in each group received subsequent doses of misoprostol by a different route than the initial administration route. Patients were There was no difference between the groups regarding the induction-to-delivery interval, duration of labor, neonatal outcome or maternal side-effects. Design: Non-blinded randomised comparative trial. Apr 30, 2020 · Induction of labour in term premature rupture of membranes; oxytocin versus sublingual misoprostol; a randomized clinical trial. 29042. 74, 95% CI 0. considered that “With a caveat of considerable uncertainty, titrated (low-dose) misoprostol solution and buccal/sublingual misoprostol had the highest likelihood of being Apr 27, 2022 · The evidence suggests mechanical induction of labour (using a balloon catheter) and misoprostol are both at least as safe and effective as using the standard drug, dinoprostone. Pregnant women are inducing labor in large numbers in both developed and developing nations. Bartusevicius et al. A total of 270 pregnant women who had spontaneous rupture of Jul 24, 2014 · Sublingual misoprostol has been compared with oral or vaginal misoprostol for induction of labour and the authors have found contradictions in outcomes related to the superiority of one route over another [14–18]. Objective: To compare sublingual with vaginal misoprostol for the induction of labor. Exclude second twin before administration. Sublingual misoprostol significantly reduces the induction-to-delivery interval and has fewer induction failures; thus, it could contribute towards reducing the morbidity Jan 1, 2019 · The aims of study was to compare the efficacy and safety profile of sublingual misoprostol (PGE2) and intracervical dinoprostone (PGE1) for cervical ripening and induction of labor. Bishop score was assessed at the time of induction and 6 h after administration of 50 Sep 15, 2022 · However, in a network meta- and cost-effectiveness analysis of labor induction methods, including 19 randomized trials of sublingual or buccal misoprostol, Alfirevic et al. Misoprostol administered by the oral and sublingual routes have the advantage of rapid onset of action, while the sublingual and vaginal routes have the advantage of prolonged activity and greatest bioavailability. Study design: This is a retrospective cohort of 130 term, nulliparous women with PROM and cervical dilation of ≤2 cm who underwent induction of labor with intravenous oxytocin or buccal misoprostol. PubMed, Cochrane Library and EMBASE searches were carried out using the keywords oral, vaginal, sublingual, buccal, misoprostol, labor induction, identifying randomized case-controlled trials comparing different routes for giving misoprostol to induce labor, published in English Sep 15, 2022 · Introduction Induction of labor (IOL) is one of the most common obstetrical procedures, with an increasing rate. Sublingual misoprostol appears to be at least as effective as when the same dose is administered orally. 14 Still, logically sublingual misoprostol, by comparison with vaginal misoprostol, has the advantage of easy administration. Misoprostol administered by the oral and sublingual routes Sep 14, 2022 · The main findings in this study were that, in primiparous women, IOL with oral misoprostol 20–40 µg every second hour resulted in a higher rate of vaginal delivery than induction with sublingual misoprostol 50 µg every 4 h, whereas the latter regime resulted in shorter labor to delivery intervals in both primiparous and parous women. 1% versus 23. The current study supported Pourali's report. Misoprostol is as a safe drug as oxytocin with low complications for the induction of labor in term pregnant women and to compare it with intravenously infused Oxytocin. Methods As A systematic review performed to compare sublingual and vaginal misoprostol for the induction of labor at term concluded that both methods were comparable and that the sublingual route had no additional clinical advantage. 38 to 16. Previous cesarean delivery was a criteria Feb 1, 2002 · Abstract. Jan 1, 2023 · Misoprostol. Apr 18, 2018 · This study was proposed with the objective of comparing the effectiveness and safety of the sublingual administration of 12. induction of labour. 2. 7 versus 36. Moeini. Jan 27, 2023 · Shetty A, Danielian P, Templeton A. Feb 1, 2018 · Sublingual misoprostol for induction of labour in PROM cases is more effective than oxytocin and its neonatal outcomes are better, and due to its easy prescription and better labour outcomes, sub lingual misOProstol may be a better choice for labour induction inPROM cases. Introduction Induction of labor (IOL) is one of the most common obstetrical procedures, with an increasing rate. In the developedWorld, the ability to induce labor has contributed to the reduction in maternal and perinatal mortality and morbidity. 5 mg of intracervical dinoprostone gel (control group). Oral misoprostol is the preferred route for induction of labor Dec 20, 2012 · Although the use of oral misoprostol for cervical ripening and labor induction is growing, its sublingual use is still limited 14–21. J Obstet Gynaecol. 1%, relative risk [RR] 0. Methods: A total of 100 patients were alternately assigned to induction with either Oct 18, 2004 · Abstract. Method Non blinded randomized prospective control study. Jul 17, 2023 · After 39 weeks gestational age, some providers or pregnant women choose have an induction (which is called an elective induction). 2. ADVERSE severe ongoing stomach discomfort or diarrhea; or. Where misoprostol remains unlicensed for the induction of labour, many practitioners will prefer to use a licensed product like dinoprostone. In mothers receiving oral 100μg misoprostol, lower doses and lesser induction is required, meconium passage is lower, frequency of vaginal delivery is higher Jun 12, 2022 · PKs of misoprostol administered for full‐term labor induction have been challenging to study due to the low (25–50 μg) doses used for this indication. The authors state. 61 1. The first group underwent Oxytocin infusion according to low-dose standard protocol and the second group received 25 μg sublingual Misoprostol every 4 h. There is evidence to suggest a balloon catheter may reduce the chance of serious negative outcomes for babies when compared with dinoprostone, and that giving low-dose Jul 21, 2023 · 57 A 2021 meta-analysis supported the use of low doses of oral misoprostol for labor induction and suggested that an initial dose of 25 mcg can offer a good balance between efficacy and safety. Sep 15, 2022 · Oral administration is considered the most safe and efficient administration of misoprostol, although more studies are needed to find the optimal route and dosage for IOL, which is associated with a significantly shorter time from induction to vaginal delivery. Sublingual misoprostol offers high efficacy as it bypasses first-pass Aug 8, 2017 · The first group underwent Oxytocin infusion according to low-dose standard protocol and the second group received 25 μg sublingual Misoprostol every 4 h. The primary outcome was time from admission to delivery. 5 μg of misoprostol (low dose) with the vaginal administration of 25 μg of misoprostol (standard recommended dose) for the induction of labor involving a live, full-term fetus. PPH prophylaxis 2 600mcg orally single dosee Not as effective as oxytocin. 91-0. Since June 2014 the first line method has been Apr 27, 2022 · The evidence suggests mechanical induction of labour (using a balloon catheter) and misoprostol are both at least as safe and effective as using the standard drug, dinoprostone. Instructions on preparing the oral solution can be found here. 1 Vaginal misoprostol has been shown to be more efficacious than oral misoprostol in equivalent doses. Objective: To compare the efficacy of sublingual misoprostol tablet and intracervical dinoprostone gel for induction of labor and also to Oct 18, 2004 · Sublingual misoprostol appears to be at least as effective as when the same dose is administered orally, and should not enter clinical use until its safety and optimal dosage have been established by larger trials. 2 There has, however, been the worry of excessive uterine contractility with vaginal doses of 50 µg or Objective: To compare the efficacy and patient acceptability of 50 microg of sublingual misoprostol with 100 microg of oral misoprostol in the induction of labour at term. Initially by vagina, or by buccal administration, or by sublingual administration Adult 800 micrograms for 1 dose, dose to be given 24–48 hours after mifepristone, if abortion has not occurred 4 hours after first misoprostol dose a further dose may be given, (by mouth or by vagina) 400 micrograms for 1 dose. Small trials Oct 1, 2019 · There was a significant difference in the post induction Bishop's score, Stage II process of labor and reduction in the requirement of augmentation (ARM) between the two groups, and misoprostol was found to be more efficacious when compared to dinoprostone. Maternal and neonatal outcomes were analyzed and risk Dec 29, 2015 · Misoprostol is an excellent labour-inducing agent and can be used liberally for labour induction, as long as proper patient selection and vigilant labour monitoring are done. Request for analgesia was similar in both groups. 5 µg of sublingual misoprostol for labor induction in women with term pregnancy and a live fetus. Maternal and neonatal outcomes were analyzed and risk tion is induction of labor (IOL). 2, 3, 4 Our own experience in comparing equivalent doses Feb 13, 2022 · The current and Pourali's studies utilized the same sublingual route of misoprostol to labor induction. Method: PubMed, Cochrane Library and EMBASE searches were carried out using the keywords oral, vaginal, sublingual, buccal, misoprostol, labor induction, identifying randomized case-controlled trials comparing different routes for giving misoprostol to induce labor Jul 8, 2021 · 25 µg starting dose appears to be safe and effective. Sep 15, 2022 · Introduction: Induction of labor (IOL) is one of the most common obstetrical procedures, with an increasing rate. Sep 1, 2020 · One RCT (n = 480) comparing sublingual and oral misoprostol, 400 mcg, found that sublingual administration was more likely to result in complete abortion (RR = 4. Fifty women received 50 micrograms of Misoprostol intravaginal (study gro up) and 50 women received 0. Abstract Premature rupture of the membranes (PROM) occurs in about 8–10% of pregnancies and its most important Study design: One hundred women with medical or obstetric indications for induction of labor after 37 weeks of gestation and unfavorable cervices were randomized to receive 50 microg of misoprostol either orally or sublingually. A randomised comparison of patient satisfaction with vaginal and sublingual misoprostol for induction of labour at term. There is evidence to suggest a balloon catheter may reduce the chance of serious negative outcomes for babies when compared with dinoprostone, and that giving low-dose Our results show that sublingual misoprostol had better efficacy that resulted in a shorter induction-to-delivery interval, with more women delivering within 24 hours of the induction compared with those using oral misoprostol. 13140/RG. BACKGROUND This is one of a series of reviews of cervical ripening and labour induction using standardised methodology. Moreover, the sublingual route is associated with a significantly higher patient Misoprostol is an excellent labour-inducing agent and can be used liberally for labour induction, as long as proper patient selection and vigilant labour monitoring are done. compared sublingual misoprostol with dinoprostone gel for induction of labor and found that both methods were equally effective for cervical ripening and labor induction. The vaginal and oral routes of administration of misoprostol are those most used for the induction of labor in routine practice, with the recommended dose being 25 μg. 8%). Sublingual misoprostol significantly reduces the induction-to-delivery interval and has fewer induction failures; thus, it could contribute towards reducing the morbidity All four trials provided data for each of the primary outcomes in all 2815 women. In the vaginal group, 66 women received a Background: Induction of labor is one of the most common interventions practiced in modern obstetrics. 6%) and buccal group (96. The prostaglandin E1 analogue misoprostol is frequently used as a primary method of For fetal death in the third trimester see 'Induction of Labour' below. 8 A Methodology: The study included 100 primigravidas with singleton pregnancy at term, having pre-labour rupture of membranes and unfavourable Bishop score with no contraindication of induction of labour, vaginal delivery or misoprostol use. Feb 13, 2022 · This study was performed to compare oxytocin and sublingual Misoprostol for labour induction in PROM cases with term pregnancy. e. 06, – 0. During 2011–2014 misoprostol 50 µg sublingually every 4 h was the first-line method of labor induction at Skane University hospital, Lund. The main reason we would give it, is to increase your chance of a vaginal birth (vs a cesarean delivery), and a healthy mom & baby. Induction of labour is recommended for women who are known with certainty to have reached 41 weeks (>40 weeks + 7 days) of gestation. Jul 27, 2020 · This study aimed at evaluating the effectiveness of misoprostol on MA induction through different routes of administration (vaginal, oral, and sublingual) in the first trimester of pregnancy. The use of sublingual misoprostol appears promising due to rapid absorption through sublingual mucosa and avoidance of first-pass metabolism [8,9], and, therefore, faster onset of action. Background: The induction of full-term labour in women with a live fetus remains a major challenge in modern obstetrics. 97), while oral misoprostol resulted 6 A. A randomized controlled trial by Agha et al. 76; 95% CI, 1. 05). Oct 18, 2004 · Shetty A, Danielian P, Templeton A. In sublingual misoprostol group out of 100 women, 99 (i. Rezvan Aalami-harandi M. 2001;108(3):238–43. The best available evidence suggests that low dose oral misoprostol probably has many benefits over other methods for labour induction. 40 Vaginal misoprostol leads to a higher rate of Sep 8, 2017 · Background Oral misoprostol as an induction of labour (IOL) agent is rapidly gaining popularity in resource-limited settings because it is cheap, stable at ambient temperatures, and logistically easier to administer compared to dinoprostone and oxytocin. Induction of labour is not recommended in women with an uncomplicated pregnancy at gestational age less than 41 weeks. 2012. The optimal dose and route of administration is yet to be ascertained. 56—0. In the present study, in the first 24 h within treatment, in most of the cases, induction resulted in complete abortion without the need for surgical compare the efficacy and safety profile of sublingual misoprostol (PGE1) and intracervical dinoprostone (PGE2) for cervical ripening and induction of labor. Oct 1, 2016 · Sublingual PGE1 is a better cervical ripening agent, faster and more effective, with a shorter induction-to-delivery interval as compared to intracervical PGE2. Sublingual misoprostol for the induction of labor at term. To evaluate the efficacy, safety, and patient acceptability of sublingual misoprostol compared with an equivalent dose administered orally for labor induction at term. The data were analysed by Statistical Feb 19, 2024 · Misoprostol can be given for cervical ripening and labor induction at a dose of 25 mcg. This study was undertaken to compare the safety and efficacy of sublingual and oral misoprostol for induction of labor at term. The prostaglandin E1 analogue misoprostol is frequently used as a primary method of labor induction. 99%) delivered vaginally Hence, misoprostol is an effective agent for induction of labor at term 6. May 4, 2021 · Efficacy and Safety of Sublingual versus Vaginal Misoprostol for Induction of Labor at Term and Post Term Pregnancies: A Randomized Clinical Trial May 2021 DOI: 10. The cases were randomized into two equal groups, A and B. We aim to investigate the safety and effectiveness of a regimen of oral misoprostol in Papua New Guinean women undergoing IOL. Induction of labour 2,5 25mcg vaginally 6-hrly or 25 mcg orally 2-hrlyd Do not use if previous caesarean section. Aug 1, 2006 · Abstract. Nov 26, 2023 · Introduction Misoprostol (prostaglandin E1 analog) is being used for the induction of labor by vaginal, oral, and sublingual routes. AbstractBackground Prostaglandins are popular agents for induction of labour, owing to their dual action of cervical ripening and inducing uterine contractions. American Journal of Obstetrics and Gynecology 2002; 186 (1):72‐6. Jan 1, 2002 · Misoprostol, a synthetic prostaglandin E 1 analog, has been given both orally and vaginally for induction of labor at term. Call your doctor for medical advice about side effects. TLDR. Sublingual Misoprostol is an effective alternative to vaginal Misoprostol in induction of labour 4. Background: Sublingual misoprostol and intracervical dinoprostone gel are used for induction of labor. 2 There has, however, been the worry of excessive uterine contractility with vaginal doses of 50 μg or higher. Second stage of labour was significantly shorter in misoprostol group (p < . If gestational diabetes is the only abnormality, induction of labour Aug 29, 2016 · Patients undergoing induction of labour after 36 weeks of pregnancy were allocated by randomization to induction of labour with oral misoprostol solution administered 2 h apart. 17). 05 Abstract: Objective: To compare the efficacy of sublingual misoprostol tablet and intracervical dinoprostone gel for induction of labour in nulliparous postdated pregnancy and assess the maternal and fetal outcome after induction. Methodology: It is a prospective randomized controlled study conducted over a period of 2 years (nov Background: Purpose of this study was to evaluate the efficacy and safety of different routes of administration of misoprostol - 50µg oral, 25µg vaginal and 50µg sublingual for induction of labour in women with premature rupture of membranes after 34 May 29, 2023 · of sublingual misoprostol and intracervical dinoprostone g el for induction of labor in primigravida women. The benefits of IOL (where clinically indicated) in pregnancies at or beyond term include improvement of neonatal and maternal outcomes and reducing the risk of cesarean sections Citation 2. Mar 1, 2016 · In terms of labour induction and maternal outcomes in the post-term pregnant women, oral misoprostol 100μg is more useful than misoprostol 50 μg or the vaginal type of the medication. 9). Sublingual or buccal routes should be avoided. This review supports the use of low dose oral misoprostol for induction of labour, and demonstrates the lower risks of hyperstimulation Misoprostol has also been shown to be effective for induction of labor with a viable fetus. These two women were assigned to group based on route of initial dose. 23 Dec 29, 2015 · Misoprostol is an excellent labour-inducing agent and can be used liberally for labour induction, as long as proper patient selection and vigilant labour monitoring are done. ka et vg ld vs af je ki rd wl